
Owing to the rich source of polyphenols (such as anthocyanins (ACNs), flavanols, and pterostilbene), BBs display a variety of biological activities in vitro and in vivo for the prevention of carcinogenesis, including the inhibition of the production of pro-inflammatory molecules, oxidative stress, and the products of oxidative stress, such as DNA damage (with 400 µg/mL ACN in rat models), cancer cell proliferation (with 40 µg/mL pterostilbene in rat models), and an increase in apoptosis (with 50–150 µg/mL ACN). Interestingly, BBs have been labeled a “super fruit” or “superfood” for their ability to prevent or mitigate several diseases, such as cardiovascular diseases, diabetes, and cancer. Blueberries (BBs) are one of the fastest growing fresh produce categories due to the high demand of customers, who have demonstrated an increased awareness of BBs’ benefits to human health. It has been well established that a rich diet of fruits and vegetables yields sustainable health benefits and reduces risks of lifestyle-associated health conditions.

Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries all of these aspects are covered in this review. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children.

Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system.
